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- * Plant viruses icosahedral capsid proteins 'S' region signature *
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-
- The capsid protein of plant icosahedral positive strand RNA viruses generally
- consists of four distinct domains: an N-terminal positively charged 'R' domain
- involved in the interaction with RNA, a connecting arm 'a', a central domain
- 'S' forming the virion shell, and a C-terminal projecting 'P' domain. Some of
- the viruses lack either the R or P domains.
-
- It has been shown [1] that the S domain of the capsid protein of a number of
- plant viruses are evolutionary related, namely
-
- - Carmoviruses: carnation mottle virus (CarMV), melon necrotic spot virus
- (MNSV), and turnip crinkle virus (TCV).
- - Dianthoviruses: red clover necrotic mosaic virus (RCNMV).
- - Sobemoviruses: maize chlorotic mottle virus (MCMV), and southern bean
- mosaic virus (SBMV).
- - Tombusviruses: artichoke mottled crinkle virus (AMCV), cucumber necrosis
- virus (CNV), cymbidium ringspot virus (CyRSV), and tomato bushy stunt virus
- (TBSV).
- - Tobacco necrosis virus (TNV).
-
- The S domain of these viruses contains from 158 to 166 amino acids and is
- composed of eight beta-strand anti-parallel twisted sheets in what is known as
- a 'jellyroll' conformation. The signature pattern for this domain starts at
- the C-terminal part of the 3rd beta-strand and extends up to the end of the
- 4th strand.
-
- -Consensus pattern: [FYW]-x-[PSTA]-x(7)-G-x-[LIVM]-x-[LIVM]-x-[FYW]-x(2)-D-
- x(5)-P
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Expert(s) to contact by email: Koonin E.V.
- koonin@ncbi.nlm.nih.gov
-
- -Last update: October 1993 / Text revised.
-
- [ 1] Dolja V.V., Koonin E.V.
- J. Gen. Virol. 72:1481-1486(1991).
-